Protein Name:
Structural maintenance of chromosomes protein 1A
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UniprotKB/SwissProt ID: Q14683 (Q14683)
Gene Name:
SMC1A
Organism: Homo sapiens (Human)
Function: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome. Chromosome, centromere, kinetochore
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14683
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1073 |
KKERFDRFNA C FESVATNIDE |
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| 2 |
1115 |
EPYLDGINYN C VAPGKRFRPM |
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| 3 |
1180 |
VANYIKEQST C NFQAIVISLK |
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| 4 |
1210 |
LIGVYPEQGD C VISKVLTFDL |
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| 5 |
933 |
RSDRHNLLQA C KMQDIKLPLS |
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| 6 |
987 |
ALIEIDYGDL C EDLKDAQAEE |
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