Protein Name:
DNA replication licensing factor MCM6
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UniprotKB/SwissProt ID: Q14566 (Q14566)
Gene Name:
MCM6
Organism: Homo sapiens (Human)
Function: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14566
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
158 |
HPELVSGTFL C LDCQTVIRDV |
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| 2 |
161 |
LVSGTFLCLD C QTVIRDVEQQ |
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| 3 |
180 |
QQFKYTQPNI C RNPVCANRRR |
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| 4 |
185 |
TQPNICRNPV C ANRRRFLLDT |
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| 5 |
242 |
AVESAQAGDK C DFTGTLIVVP |
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| 6 |
301 |
DLSYRLVFLA C CVAPTNPRFG |
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| 7 |
302 |
LSYRLVFLAC C VAPTNPRFGG |
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| 8 |
351 |
SQDKNLYHNL C TSLFPTIHGN |
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| 9 |
393 |
GTSLRGDINV C IVGDPSTAKS |
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| 10 |
540 |
FDLFFILVDE C NEVTDYAIAR |
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| 11 |
637 |
LSEAMARMHC C DEVQPKHVKE |
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| 12 |
721 |
ASLRLGFSEY C RISNLIVLHL |
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| 13 |
91 |
EEFYRVYPYL C RALKTFVKDR |
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