Protein Name:
Helicase-like transcription factor
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UniprotKB/SwissProt ID: Q14527 (Q14527)
Gene Name:
HLTF
Organism: Homo sapiens (Human)
Function: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14527
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
360 |
ADGLSKDASR C SEQPSISDIK |
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| 2 |
442 |
SKVIEDVAFA C ALTSSVPTTK |
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| 3 |
812 |
NDIHEDNLLE C PPEELARDSE |
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| 4 |
942 |
PAWNPAAEDQ C FDRCHRLGQK |
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