Protein Name:
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
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UniprotKB/SwissProt ID: Q14432 (Q14432)
Gene Name:
PDE3A
Organism: Homo sapiens (Human)
Function: Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:1315035, PubMed:25961942, PubMed:8155697, PubMed:8695850). Also has activity toward cUMP (PubMed:27975297). Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:34707099)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14432
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
303 |
SSVVSAEMSG C SSKSHRRTSL |
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| 2 |
315 |
SKSHRRTSLP C IPREQLMGHS |
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| 3 |
407 |
PVTSLSENYT C SDSEESSEKD |
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| 4 |
526 |
LAKISPLSSP C SSPLQGTPAS |
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| 5 |
645 |
DIVQNEDETE C LREPLRKASA |
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