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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cytoplasmic dynein 1 heavy chain 1
UniprotKB/SwissProt ID: Q14204 (Q14204)

Gene Name: DYNC1H1

Organism: Homo sapiens (Human)

Function: Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC
IPR054354 DYNC2H1-like_lid
IPR042222 Dynein_2_N
IPR043157 Dynein_AAA1S
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR043160 Dynein_C_barrel
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013602 Dynein_heavy_linker
IPR013594 Dynein_heavy_tail
IPR042228 Dynein_linker_3
IPR027417 P-loop_NTPase
The S-nitrosylation sites of Q14204
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1059 QYVKVWLQYQ C LWDMQAENIY  CCCCCCCCCC C CCCCCEEEEE  3.36%
2 1888 KLVQTPLTDR C YLTMTQALEA  CCCCCCCCCC C CCCCCEEEEE  3.48%
3 1977 MLSAVSQQVQ C IQEALREHSN  CCCCCCCCCC C CCCCCEEEEE  3.49%
4 1999 NYDKTSAPIT C ELLNKQVKVS  CCCCCCCCCC C CCCCCEEEEE  3.43% 2212679
5 2076 ANKIVPFFKL C DEQLSSQSHY  CCCCCCCCCC C CCCCCEEEEE  5.8% 37478858
6 2142 PEQEILIQSV C ETMVPKLVAE  CCCCCCCCCC C CCCCCEEEEE  4.34%
7 2639 ELLLKTFDHY C EYRRTPNGVV  CCCCCCCCCC C CCCCCEEEEE  3.12%
8 2712 KLERIQFVGA C NPPTDPGRKP  CCCCCCCCCC C CCCCCEEEEE  6.9%
9 3033 GDEYATLMTQ C KEGAQKEGLM  CCCCCCCCCC C CCCCCEEEEE  2.97%
10 3147 PSHREAIVNS C VFVHQTLHQA  CCCCCCCCCC C CCCCCEEEEE  2.02% 37478858
11 3325 AAVKLALESI C LLLGESTTDW  CCCCCCCCCC C CCCCCEEEEE  2.81%
12 3573 QASSLPADDL C TENAIMLKRF  CCCCCCCCCC C CCCCCEEEEE  6.04%
13 3712 TVTRSSLQSQ C LNEVLKAERP  CCCCCCCCCC C CCCCCEEEEE  5.51%
14 3940 EQAEAVVRLS C LPAFKDLIAK  CCCCCCCCCC C CCCCCEEEEE  6.63% 37478858
15 4121 KKLHSLQPHA C FRLFLTMEIN  CCCCCCCCCC C CCCCCEEEEE  1.53%
16 4216 EFGESDLRSA C DTVDTWLDDT  CCCCCCCCCC C CCCCCEEEEE  4.8%
17 4438 RQDLADVVQV C EGKKKQTNYL  CCCCCCCCCC C CCCCCEEEEE  2.97%
18 4510 GAKELKNIHV C LGGLFVPEAY  CCCCCCCCCC C CCCCCEEEEE  1.48%
19 4570 VTGLKLQGAT C NNNKLSLSNA  CCCCCCCCCC C CCCCCEEEEE  5.2%
20 4644 SFYERGVAVL C TE--------  CCCCCCCCCC C CCCCCEEEEE  3.02%
21 633 FKVQYPQSQA C KMSHVRDLPP  CCCCCCCCCC C CCCCCEEEEE  2.7%
22 867 IDLEVRSLET C MYDHKTFSEI  CCCCCCCCCC C CCCCCEEEEE  1.41% 37478858
23 978 VIYLNPPIEE C RYKLYQEMFA  CCCCCCCCCC C CCCCCEEEEE  3.6%