Protein Name:
DNA polymerase alpha subunit B
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UniprotKB/SwissProt ID: Q14181 (Q14181)
Gene Name:
POLA2
Organism: Homo sapiens (Human)
Function: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14181
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
198 |
AGNISLKVLG C PEALTGSYKS |
CCHHHHHHHH H HHHHCCCHHH |
2.11% |
19483679
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| 2 |
259 |
EPVTLLGQIG C DSNGKLNNKS |
CCHHHHHHHH H HHHHCCCHHH |
5.76% |
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| 3 |
392 |
LDAKHEQVEN C LLTSPFEDIF |
CCHHHHHHHH H HHHHCCCHHH |
1.77% |
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| 4 |
590 |
AADGAERQSP C IAVQVVRI-- |
CCHHHHHHHH H HHHHCCCHHH |
3.65% |
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