Protein Name:
Rho guanine nucleotide exchange factor 7
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UniprotKB/SwissProt ID: Q14155 (Q14155)
Gene Name:
ARHGEF7
Organism: Homo sapiens (Human)
Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, lamellipodium
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14155
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
490 |
VTYMSQVLIQ C AGSEEKNERY |
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| 2 |
721 |
AQILKVIEAY C TSAKTRQTLN |
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