Protein Name:
MORC family CW-type zinc finger protein 3
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UniprotKB/SwissProt ID: Q14149 (Q14149)
Gene Name:
MORC3
Organism: Homo sapiens (Human)
Function: Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response (PubMed:27440897, PubMed:34759314). Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function (PubMed:34759314). Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity (PubMed:17332504, PubMed:20501696). Binds RNA in vitro (PubMed:11927593). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034) (Microbial infection) May be required for influenza A transcription during viral infection (PubMed:26202233)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleoplasm. Nucleus matrix. Nucleus, PML body. Chromosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14149
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
446 |
SNNPDPQFRN C EVPEEPEDED |
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| 2 |
619 |
QVEFVGDSEP C GQTGSTSTSS |
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| 3 |
632 |
TGSTSTSSSR C DQGNTAATQT |
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| 4 |
671 |
VRNDAVILPS C VEAEAKIHET |
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| 5 |
694 |
TTDKSADDAG C QLQELRNQLL |
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