Protein Name:
Tripartite motif-containing protein 29
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UniprotKB/SwissProt ID: Q14134 (Q14134)
Gene Name:
TRIM29
Organism: Homo sapiens (Human)
Function: Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Lysosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14134
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
176 |
SGSEEVLCDS C IGNKQKAVKS |
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