Protein Name:
Interleukin-18
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UniprotKB/SwissProt ID: Q14116 (Q14116)
Gene Name:
IL18
Organism: Homo sapiens (Human)
Function: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:10653850). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532, PubMed:37993714). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (PubMed:10653850). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q14116
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
112 |
VKCEKISTLS C ENKIISFKEM |
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| 2 |
163 |
SSSYEGYFLA C EKERDLFKLI |
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| 3 |
74 |
PLFEDMTDSD C RDNAPRTIFI |
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