Protein Name:
Rap guanine nucleotide exchange factor 1
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UniprotKB/SwissProt ID: Q13905 (Q13905)
Gene Name:
RAPGEF1
Organism: Homo sapiens (Human)
Function: Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1 (PubMed:12432078). Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q13905
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
958 |
KQTSEGLAEY C TLIDSSSSFR |
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