UniprotKB/SwissProt ID: Q13639 (Q13639)
Gene Name:
HTR4
Organism: Homo sapiens (Human)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:10821780, PubMed:16102731, PubMed:35714614, PubMed:9603189). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:16102731, PubMed:35714614). HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:16102731, PubMed:35714614)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Endosome membrane
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