Protein Name:
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
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UniprotKB/SwissProt ID: Q13614 (Q13614)
Gene Name:
MTMR2
Organism: Homo sapiens (Human)
Function: Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11733541, PubMed:12668758, PubMed:14690594, PubMed:21372139). Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation (PubMed:35580604)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Early endosome membrane. Cytoplasm, perinuclear region. Cell projection, axon. Endosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q13614
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
155 |
GENSYGLETV C KDIRNLRFAH |
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| 2 |
237 |
ITKINERYEL C DTYPALLVVP |
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| 3 |
284 |
HPESQATITR C SQPMVGVSGK |
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| 4 |
635 |
SSERASSPAQ C VTPVQTVV-- |
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| 5 |
95 |
KDMAKDVTYI C PFTGAVRGTL |
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