Protein Name:
NEDD8-activating enzyme E1 regulatory subunit
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UniprotKB/SwissProt ID: Q13564 (Q13564)
Gene Name:
NAE1
Organism: Homo sapiens (Human)
Function: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q13564
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
294 |
SIEDIFNDDR C INITKQTPSF |
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| 2 |
384 |
SISEKELKLL C SNSAFLRVVR |
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| 3 |
483 |
MVKDDYVHEF C RYGAAEPHTI |
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