Protein Name:
Eukaryotic translation initiation factor 4E-binding protein 1
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UniprotKB/SwissProt ID: Q13541 (Q13541)
Gene Name:
EIF4EBP1
Organism: Homo sapiens (Human)
Function: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q13541
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
62 |
IIYDRKFLME C RNSPVTKTPP |
CCCCCCCCCC C CCCCCCCCEE |
2.88% |
24105792
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| 2 |
7 |
----MSGGSS C SQTPSRAIPA |
CCCCCCCCCC C CCCCCCCCEE |
3.61% |
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