Protein Name:
Tubulin beta-3 chain
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UniprotKB/SwissProt ID: Q13509 (Q13509)
Gene Name:
TUBB3
Organism: Homo sapiens (Human)
Function: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:34996871). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms (PubMed:34996871). Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:34996871). TUBB3 plays a critical role in proper axon guidance and maintenance (PubMed:20074521). Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, growth cone. Cell projection, lamellipodium. Cell projection, filopodium
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q13509
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
12 |
REIVHIQAGQ C GNQIGAKFWE |
CCEEEEEECC C CCCCHHHHHH |
5.6% |
22178444
21278135
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| 2 |
124 |
DSVLDVVRKE C ENCDCLQGFQ |
CCEEEEEECC C CCCCHHHHHH |
5.23% |
37478858
|
| 3 |
127 |
LDVVRKECEN C DCLQGFQLTH |
CCEEEEEECC C CCCCHHHHHH |
1.5% |
37478858
|
| 4 |
129 |
VVRKECENCD C LQGFQLTHSL |
CCEEEEEECC C CCCCHHHHHH |
3.13% |
37478858
|
| 5 |
303 |
MFDAKNMMAA C DPRHGRYLTV |
CCEEEEEECC C CCCCHHHHHH |
5.55% |
21278135
37478858
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| 6 |
354 |
WIPNNVKVAV C DIPPRGLKMS |
CCEEEEEECC C CCCCHHHHHH |
2.57% |
21278135
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