UniprotKB/SwissProt ID: Q13478 (Q13478)
Gene Name:
IL18R1
Organism: Homo sapiens (Human)
Function: Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:14528293, PubMed:25261253, PubMed:25500532, PubMed:37993714, PubMed:8626725). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane
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