UniprotKB/SwissProt ID: Q13477 (Q13477)
Gene Name:
MADCAM1
Organism: Homo sapiens (Human)
Function: Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane
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