UniprotKB/SwissProt ID: Q13467 (Q13467)
Gene Name:
FZD5
Organism: Homo sapiens (Human)
Function: Receptor for Wnt proteins (PubMed:10097073, PubMed:20530549, PubMed:26908622, PubMed:9054360). Functions in the canonical Wnt/beta-catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (By similarity). In neurons, activation by WNT7A promotes formation of synapses (PubMed:20530549). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). Plays a role in ocular development (PubMed:26908622)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Golgi apparatus membrane. Synapse. Perikaryon. Cell projection, dendrite. Cell projection, axon
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