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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Mitogen-activated protein kinase kinase kinase 1

UniprotKB/SwissProt ID: Q13233 (Q13233)

Gene Name: MAP3K1

Organism: Homo sapiens (Human)

Function: Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR050538 MAP_kinase_kinase_kinase
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR007527 Znf_SWIM

The S-nitrosylation sites of Q13233

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1012 SKHRLQGFIP C RIPSASPQTQ