Protein Name:
Pappalysin-1
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UniprotKB/SwissProt ID: Q13219 (Q13219)
Gene Name:
PAPPA
Organism: Homo sapiens (Human)
Function: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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Graphical Visualization of S-nitrosylation Sites:
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