Protein Name:
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
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UniprotKB/SwissProt ID: Q13155 (Q13155)
Gene Name:
AIMP2
Organism: Homo sapiens (Human)
Function: Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q13155
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
143 |
LSLLVLHRLL C EHFRVLSTVH |
CCCEECCCCC C CCCCCEEECC |
4.52% |
19483679
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| 2 |
168 |
VKSVPENLLK C FGEQNKKQPR |
CCCEECCCCC C CCCCCEEECC |
5.52% |
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| 3 |
205 |
TQMKFSIQTM C PIEGEGNIAR |
CCCEECCCCC C CCCCCEEECC |
3.31% |
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| 4 |
23 |
GAPLRVELPT C MYRLPNVHGR |
CCCEECCCCC C CCCCCEEECC |
1.81% |
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| 5 |
306 |
PANVQRWMRS C ENLAPFNTAL |
CCCEECCCCC C CCCCCEEECC |
2.57% |
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