Protein Name:
Translation initiation factor eIF2B subunit epsilon
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UniprotKB/SwissProt ID: Q13144 (Q13144)
Gene Name:
EIF2B5
Organism: Homo sapiens (Human)
Function: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q13144
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
196 |
KESSPSHPTR C HEDNVVVAVD |
CCCCEECCCC E EEECCCCCCC |
4.54% |
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| 2 |
335 |
ANFTDSTTQS C THSRHNIYRG |
CCCCEECCCC E EEECCCCCCC |
2.59% |
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| 3 |
414 |
AGAQIHQSLL C DNAEVKERVT |
CCCCEECCCC E EEECCCCCCC |
4.62% |
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| 4 |
618 |
MDSPLDSSRY C ALLLPLLKAW |
CCCCEECCCC E EEECCCCCCC |
1.77% |
19483679
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