Protein Name:
Acetyl-CoA carboxylase 1
|
UniprotKB/SwissProt ID: Q13085 (Q13085)
Gene Name:
ACACA
Organism: Homo sapiens (Human)
Function: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20457939, PubMed:20952656, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20457939, PubMed:20952656, PubMed:29899443)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q13085
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1009 |
TQFQNGHYDK C VFALREENKS |
|
|
|
| 2 |
1116 |
SAIDMYGHQF C IENLQKLILS |
|
|
|
| 3 |
1176 |
VQHRQLKDNT C VVEFQFMLPT |
|
|
|
| 4 |
1297 |
HILNVAIKTD C DIEDDRLAAM |
|
|
|
| 5 |
1396 |
MRNFDLTAIP C ANHKMHLYLG |
|
|
|
| 6 |
1769 |
KRVSALNSVH C EHVEDEGESR |
|
|
|
| 7 |
500 |
IDFEDSAHVP C PRGHVIAARI |
|
|
|
| 8 |
813 |
KRPGAALDPG C VLAKMQLDNP |
|
|
|
|
