Protein Name:
Protein flightless-1 homolog
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UniprotKB/SwissProt ID: Q13045 (Q13045)
Gene Name:
FLII
Organism: Homo sapiens (Human)
Function: Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (By similarity). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By similarity). Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (By similarity). May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1 (PubMed:14966289). Involved in estrogen hormone signaling
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, podosome. Cell junction, focal adhesion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q13045
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
119 |
LDLSHNQLTE C PRELENAKNM |
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| 2 |
232 |
LSNLADVDLS C NDLTRVPECL |
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| 3 |
241 |
SCNDLTRVPE C LYTLPSLRRL |
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| 4 |
289 |
NQLTSLPSAI C KLSKLKKLYL |
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| 5 |
337 |
NNLELVPESL C RCPKLRKLVL |
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| 6 |
527 |
AFHGKFYEAD C YIVLKTFLDD |
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| 7 |
560 |
GGEATLDKKA C SAIHAVNLRN |
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| 8 |
576 |
VNLRNYLGAE C RTVREEMGDE |
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