Protein Name:
Transcriptional repressor NF-X1
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UniprotKB/SwissProt ID: Q12986 (Q12986)
Gene Name:
NFX1
Organism: Homo sapiens (Human)
Function: Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q12986
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
295 |
DLNERPAKST C DSENLAVINK |
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| 2 |
542 |
YCGSTSRDVL C GTDVGKSDGF |
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| 3 |
557 |
GKSDGFGDFS C LKICGKDLKC |
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| 4 |
711 |
EICCVDKEHK C PLICGRKLRC |
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| 5 |
856 |
CLVDEPCKQP C TTPRADCGHP |
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| 6 |
92 |
SQQTSFQSSP C NKSPKSHGLQ |
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