Protein Name:
Active breakpoint cluster region-related protein
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UniprotKB/SwissProt ID: Q12979 (Q12979)
Gene Name:
ABR
Organism: Homo sapiens (Human)
Function: Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form (PubMed:17116687, PubMed:7479768). The central Dbl homology (DH) domain functions as a guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (PubMed:7479768). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, dendritic spine. Cell projection, axon. Synapse
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q12979
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
201 |
YKVALETAEK C SQSNNQFQKI |
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