Protein Name:
Unconventional myosin-Ie
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UniprotKB/SwissProt ID: Q12965 (Q12965)
Gene Name:
MYO1E
Organism: Homo sapiens (Human)
Function: Actin-based motor molecule with ATPase activity (PubMed:11940582, PubMed:36316095). Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Involved in clathrin-mediated endocytosis and intracellular movement of clathrin-coated vesicles (PubMed:36316095). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Cell junction
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q12965
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
107 |
RNMIIDRENQ C VIISGESGAG |
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| 2 |
447 |
PIEYFNNKIV C DLIENKVNPP |
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| 3 |
519 |
GKVSYDMDGF C ERNRDVLFMD |
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| 4 |
790 |
VKRDLLLTPK C LYLIGREKVK |
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