UniprotKB/SwissProt ID: Q12955 (Q12955)
Gene Name:
ANK3
Organism: Homo sapiens (Human)
Function: Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (PubMed:7836469). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (By similarity) May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, axon. Cell membrane, sarcolemma. Postsynaptic cell membrane. Lysosome. Cell membrane, sarcolemma, T-tubule. Cytoplasm, cytoskeleton. Golgi apparatus
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