Protein Name:
Heat shock protein 75 kDa, mitochondrial
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UniprotKB/SwissProt ID: Q12931 (Q12931)
Gene Name:
TRAP1
Organism: Homo sapiens (Human)
Function: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q12931
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
501 |
RAGTRNIYYL C APNRHLAEHS |
CHHHHHHHHH H HHHHHHHHHC |
3.23% |
19483679
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| 2 |
573 |
KFEDRSPAAE C LSEKETEELM |
CHHHHHHHHH H HHHHHHHHHC |
4.31% |
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