Protein Name:
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
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UniprotKB/SwissProt ID: Q12904 (Q12904)
Gene Name:
AIMP1
Organism: Homo sapiens (Human)
Function: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm, cytosol. Secreted. Endoplasmic reticulum. Golgi apparatus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q12904
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
161 |
DVSRLDLRIG C IITARKHPDA |
CCCHHHHHHH H HHCCCCHHHH |
1.57% |
19483679
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| 2 |
229 |
RGVLSQAMVM C ASSPEKIEIL |
CCCHHHHHHH H HHCCCCHHHH |
1.95% |
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| 3 |
284 |
IQPDLHTNDE C VATYKGVPFE |
CCCHHHHHHH H HHCCCCHHHH |
2.55% |
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