Protein Name:
Nucleosome-remodeling factor subunit BPTF
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UniprotKB/SwissProt ID: Q12830 (Q12830)
Gene Name:
BPTF
Organism: Homo sapiens (Human)
Function: Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:14609955, PubMed:28801535). The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex (PubMed:28801535). Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development (PubMed:14609955). Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes (PubMed:16728976, PubMed:16728978). Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent (PubMed:16728976, PubMed:16728978, PubMed:18042461). May also regulate transcription through direct binding to DNA or transcription factors (PubMed:10575013)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q12830
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1137 |
ELLDSDSDKP C KEEPMEVDDD |
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| 2 |
1266 |
NDQPEDLIQG C SESDSSVLRM |
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| 3 |
1460 |
QDVEVLEPLK C ELVSGESTGN |
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| 4 |
1648 |
STQTTTPSAS C PESNSVNQVE |
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| 5 |
1746 |
KQTVVSSTEN C AKSTVTTTTT |
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| 6 |
20 |
KQPAAPAAER C APAPPPPPPP |
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