UniprotKB/SwissProt ID: Q12246 (Q12246)
Gene Name:
LCB4
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively (PubMed:11102354, PubMed:11795842, PubMed:16141212, PubMed:25345524, PubMed:9677363). Involved in the biosynthesis of sphingolipids and ceramides (PubMed:12493772). Required with LCB3 for an effective incorporation of DHS into ceramides through a phosphorylation-dephosphorylation cycle. Involved in heat-induced transient cell cycle arrest (PubMed:11056159). Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling (PubMed:11278643). Involved in heat-stress resistance (PubMed:11967828)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Endoplasmic reticulum membrane. Late endosome membrane. Golgi apparatus membrane
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