UniprotKB/SwissProt ID: Q10651 (Q10651)
Gene Name:
apl-1
Organism: Caenorhabditis elegans
Function: Required for normal developmental progression throughout all life stages (PubMed:18262516, PubMed:22466039). Specifically required for the molt stage during all larval transitions and morphogenesis (PubMed:17267616, PubMed:18262516, PubMed:22466039). Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition (PubMed:18262516, PubMed:28933985). Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells (PubMed:28933985). Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg-laying (PubMed:22466039). May play a role in neurotransmission (PubMed:20862215)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Early endosome
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