Protein Name:
F-BAR domain only protein 2
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UniprotKB/SwissProt ID: Q0JRZ9 (Q0JRZ9)
Gene Name:
FCHO2
Organism: Homo sapiens (Human)
Function: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane, clathrin-coated pit
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q0JRZ9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
273 |
ERPGLIEFEE C DTASAVEGIK |
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| 2 |
621 |
AQLVFSDPSQ C DSNTKDFWMN |
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| 3 |
86 |
FKTSTEKLAN C HLDLVRKLQE |
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