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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

UniprotKB/SwissProt ID: Q0II26 (Q0II26)

Gene Name: AIMP2

Organism: Bos taurus (Bovine)

Function: Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR042360 AIMP2
IPR031889 AIMP2_LysRS-bd
IPR041503 AIMP2_thioredoxin
IPR036282 Glutathione-S-Trfase_C_sf
IPR004046 GST_C

The S-nitrosylation sites of Q0II26

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 291 LWSVLRQTGG C GGMAPANVQK