Protein Name:
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
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UniprotKB/SwissProt ID: Q09324 (Q09324)
Gene Name:
Gcnt1
Organism: Mus musculus (Mouse)
Function: Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. The catalysis is metal ion-independent and occurs with inversion of the anomeric configuration of sugar donor (PubMed:12954635, PubMed:22056345, PubMed:9881978). Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (PubMed:9881978). Can also act on glycolipid substrates. Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage-specific embryonic antigen 1 (SSEA-1) determinant (PubMed:7983056). Can use Galbeta1-3GalNAcalpha1-R and Galbeta1-3GalNAcbeta1-R oligosaccharide derivatives as acceptor substrates (PubMed:7983056)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus membrane
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR003406
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Glyco_trans_14 |
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