Protein Name:
Peptidyl-prolyl cis-trans isomerase D
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UniprotKB/SwissProt ID: Q08752 (Q08752)
Gene Name:
PPID
Organism: Homo sapiens (Human)
Function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q08752
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
176 |
EVKGEKPAKL C VIAECGELKE |
CCCCCCCCCC C CCCCCEEEEE |
1.73% |
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| 2 |
275 |
RAKLQPIALS C VLNIGACKLK |
CCCCCCCCCC C CCCCCEEEEE |
4.14% |
19483679
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| 3 |
282 |
ALSCVLNIGA C KLKMSNWQGA |
CCCCCCCCCC C CCCCCEEEEE |
4.47% |
19483679
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| 4 |
296 |
MSNWQGAIDS C LEALELDPSN |
CCCCCCCCCC C CCCCCEEEEE |
3.36% |
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| 5 |
71 |
TTGKPLHFKG C PFHRIIKKFM |
CCCCCCCCCC C CCCCCEEEEE |
3.16% |
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