UniprotKB/SwissProt ID: Q08334 (Q08334)
Gene Name:
IL10RB
Organism: Homo sapiens (Human)
Function: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane
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