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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Quinone oxidoreductase

UniprotKB/SwissProt ID: Q08257 (Q08257)

Gene Name: CRYZ

Organism: Homo sapiens (Human)

Function: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR013149 ADH-like_C
IPR013154 ADH-like_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS
IPR051603 Zinc-ADH_QOR/CCCR

The S-nitrosylation sites of Q08257

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 145 TAYRALIHSA C VKAGESVLVH  CCHHHHHHHH H HHHCCCCHHH  3.46%
2 166 GASGGVGLAA C QIARAYGLKI  CCHHHHHHHH H HHHCCCCHHH  2.21%
3 45 DHQVLIKVHA C GVNPVETYIR  CCHHHHHHHH H HHHCCCCHHH  3.64% 24105792