UniprotKB/SwissProt ID: Q08024 (Q08024)
Gene Name:
Cbfb
Organism: Mus musculus (Mouse)
Function: Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3) (PubMed:12434156, PubMed:8386878, PubMed:8497254). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX (PubMed:12434156, PubMed:8386878, PubMed:8497254). The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (PubMed:11257229). CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development (PubMed:18258917). They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation (PubMed:18258917)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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