Protein Name:
DNA polymerase epsilon catalytic subunit A
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UniprotKB/SwissProt ID: Q07864 (Q07864)
Gene Name:
POLE
Organism: Homo sapiens (Human)
Function: Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in chromosomal DNA replication (By similarity). Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Involved in DNA synthesis during DNA repair (PubMed:20227374, PubMed:27573199). Along with DNA polymerase POLD1 and DNA polymerase POLK, has a role in excision repair (NER) synthesis following UV irradiation (PubMed:20227374)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q07864
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1612 |
VLEEFPLVPI C VADKINYGVL |
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| 2 |
2158 |
CRSYVLPEVI C RSCNFCRDLD |
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| 3 |
445 |
DPVELDPEDM C RMATEQPQTL |
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