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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Induced myeloid leukemia cell differentiation protein Mcl-1

UniprotKB/SwissProt ID: Q07820 (Q07820)

Gene Name: MCL1

Organism: Homo sapiens (Human)

Function: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR013281 Apop_reg_Mc1
IPR036834 Bcl-2-like_sf
IPR046371 Bcl-2_BH1-3
IPR026298 Bcl-2_fam
IPR002475 Bcl2-like
IPR020717 Bcl2_BH1_motif_CS
IPR020726 Bcl2_BH2_motif_CS
IPR020728 Bcl2_BH3_motif_CS

The S-nitrosylation sites of Q07820

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 286 KHLKTINQES C IEPLAESITD