Protein Name:
Glial cell line-derived neurotrophic factor
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UniprotKB/SwissProt ID: Q07731 (Q07731)
Gene Name:
Gdnf
Organism: Rattus norvegicus (Rat)
Function: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:10828539). Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor (By similarity). May also modulate local neuronal effects in distal regions of the motor neuron (PubMed:10828539). Involved in the development of the neural crest (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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Graphical Visualization of S-nitrosylation Sites:
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