Protein Name:
Cation-independent mannose-6-phosphate receptor
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UniprotKB/SwissProt ID: Q07113 (Q07113)
Gene Name:
Igf2r
Organism: Mus musculus (Mouse)
Function: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus membrane. Endosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q07113
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
129 |
HRIQTSITFL C GKTLGTPEFV |
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