UniprotKB/SwissProt ID: Q06147 (Q06147)
Gene Name:
LCB5
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS or sphinganine) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1-phosphate (PHS-1P) respectively (PubMed:11102354, PubMed:12493772, PubMed:25345524, PubMed:9677363). Redundant to LCB4, is only responsible for few percent of the total activity (PubMed:9677363). Involved in the biosynthesis of sphingolipids and ceramides (PubMed:25345524, PubMed:9677363). Involved in heat-induced transient cell cycle arrest (PubMed:11056159). Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling (PubMed:11102354, PubMed:11278643). Involved in heat-stress resistance (PubMed:11056159)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus membrane
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