Protein Name:
Tyrosine-protein phosphatase non-receptor type 11
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UniprotKB/SwissProt ID: Q06124 (Q06124)
Gene Name:
PTPN11
Organism: Homo sapiens (Human)
Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669, PubMed:18829466, PubMed:26742426, PubMed:28074573). Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (PubMed:18559669). Dephosphorylates CDC73 (PubMed:26742426). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (PubMed:19275884)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q06124
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
104 |
DVIELKYPLN C ADPTSERWFH |
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| 2 |
259 |
EEFETLQQQE C KLLYSRKEGQ |
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| 3 |
333 |
PKKSYIATQG C LQNTVNDFWR |
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| 4 |
459 |
IMDAGPVVVH C SAGIGRTGTF |
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| 5 |
486 |
IDIIREKGVD C DIDVPKTIQM |
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| 6 |
569 |
PLPPCTPTPP C AEMREDSARV |
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