Protein Name:
Basement membrane-specific heparan sulfate proteoglycan core protein
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UniprotKB/SwissProt ID: Q05793 (Q05793)
Gene Name:
Hspg2
Organism: Mus musculus (Mouse)
Function: Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (By similarity) Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6 (By similarity) Has anti-angiogenic properties that require binding of calcium ions for full activity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q05793
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1697 |
VPQGGPHSLR C QVSGSPPHYF |
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| 2 |
1792 |
VRPGADVTFI C TAKSKSPAYT |
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| 3 |
1932 |
IEPSDQGQYL C RALSSAGQHV |
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| 4 |
2742 |
RNIGASVEFH C AVPNERGTHL |
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| 5 |
3137 |
KAGLSSGFVG C VRELRIQGEE |
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