Protein Name:
Cytochrome P450 2E1
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UniprotKB/SwissProt ID: Q05421 (Q05421)
Gene Name:
Cyp2e1
Organism: Mus musculus (Mouse)
Function: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Microsome membrane. Mitochondrion inner membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q05421
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
261 |
KEHLKSLDIN C PRDVTDCLLI |
CCHHHHHHHH H HHHHHHHHHH |
2.74% |
22178444
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| 2 |
268 |
DINCPRDVTD C LLIEMEKEKH |
CCHHHHHHHH H HHHHHHHHHH |
2.14% |
22178444
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| 3 |
437 |
FKAFSAGKRV C VGEGLARMEL |
CCHHHHHHHH H HHHHHHHHHH |
3.65% |
22178444
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| 4 |
488 |
FGSIPREFKL C VIPRS----- |
CCHHHHHHHH H HHHHHHHHHH |
2.41% |
22178444
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