Protein Name:
Tyrosine-protein phosphatase non-receptor type 12
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UniprotKB/SwissProt ID: Q05209 (Q05209)
Gene Name:
PTPN12
Organism: Homo sapiens (Human)
Function: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell junction, focal adhesion. Cell projection, podosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q05209
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
343 |
PPPKPPRTRS C LVEGDAKEEI |
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| 2 |
470 |
HAIKIKSASP C IADKISKPQE |
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| 3 |
495 |
LNVGDTSQNS C VDCSVTQSNK |
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